Development of Scaffold-Free Elastic Cartilaginous Constructs with Structural Similarities to Auricular Cartilage
نویسندگان
چکیده
منابع مشابه
Bioengineering Human Scaffold-free Cartilage Constructs Using Paediatric Auricular Tissue
Currently, patients with external ear deformities rely on hyaline cartilage grafts or silicone prosthesis to provide them with adequate external ear reconstruction. Scaffold-free auricular tissue engineering provides a means of creating patient specific cartilage constructs solely using their own cells, ensuring biocompatibility, long term stability, and reduced morbidity. Here, we have develop...
متن کاملGrowth Factor Stimulation Improves the Structure and Properties of Scaffold-Free Engineered Auricular Cartilage Constructs
The reconstruction of the external ear to correct congenital deformities or repair following trauma remains a significant challenge in reconstructive surgery. Previously, we have developed a novel approach to create scaffold-free, tissue engineering elastic cartilage constructs directly from a small population of donor cells. Although the developed constructs appeared to adopt the structural ap...
متن کاملMethods for Producing Scaffold-Free Engineered Cartilage Sheets from Auricular and Articular Chondrocyte Cell Sources and Attachment to Porous Tantalum
Scaffold-free cartilage engineering techniques may provide a simple alternative to traditional methods employing scaffolds. We previously reported auricular chondrocyte-derived constructs for use in an engineered trachea model; however, the construct generation methods were not reported in detail. In this study, methods for cartilage construct generation from auricular and articular cell source...
متن کاملAbstract: Scaffolding the Scaffold: 3D-Printed External Biodegradable Cage Mitigates Contraction during Maturation of Elastic Cartilage Constructs
1. Kythera Biopharmaceuticals I. Dermatologic and ophthalmic drugs advisory committee briefing document: ATX-101 (deoxycholic acid) injection. https:// www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/DermatologicandOphthalmicDrugsAdvisoryCommittee/UCM436604.pdf. Accessed February 26, 2017. 2. Dayan SH, Humphrey S, Jones DH, et al. Overview of ATX-101 (Deoxycholic Acid ...
متن کاملAdipose Tissue Engineering: Comparing Scaffold-free and Fibrin-based Constructs
Introduction Success of adipose tissue engineering for soft tissue repair has been limited by poor cell survival and insufficient adipogenic differentiation. Although the choice of scaffold can influence these parameters, there is a limited number of studies focussing on the role of scaffolds in cell survival and. adipogenic differentiation. In this study we examined how three-dimensional scaff...
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ژورنال
عنوان ژورنال: Tissue Engineering Part A
سال: 2014
ISSN: 1937-3341,1937-335X
DOI: 10.1089/ten.tea.2013.0159